HPLC with Electrochemical Detection for Plasma Pharmacokinetic Studies
نویسندگان
چکیده
منابع مشابه
HPLC Determination of Esculin and Esculetin in Rat Plasma for Pharmacokinetic Studies.
An optimized, sensitive and validated reversed-phase high-performance liquid chromatography (RP-HPLC) method with UV detection is described for simultaneous determination of esculin and its aglycone, esculetin, in rat plasma. After addition of internal standard (chrysin), plasma samples were pretreated by solid-phase extraction and introduced into the HPLC system. Analytes were separated on a R...
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A simple and reproducible HPLC method with spectrophotometric detection was developed for determination of rivastigmine in human plasma. Liquid-liquid extraction of rivastigmine and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. Chromatography was carried out using ...
متن کاملHigh-Performance Liquid Chromatographic Determination of Rivastig-mine in Human Plasma for Application in Pharmacokinetic Studies
A simple and reproducible HPLC method with spectrophotometric detection was developed for determination of rivastigmine in human plasma. Liquid-liquid extraction of rivastigmine and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. Chromatography was carried out using ...
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ژورنال
عنوان ژورنال: BUNSEKI KAGAKU
سال: 2015
ISSN: 0525-1931
DOI: 10.2116/bunsekikagaku.64.821